急问，美国有没有什么抗肺癌新药？

晒太阳的猫 · Post by **晒太阳的猫** » 2005-09-10 11:30

是小细胞癌症，3A期，首次化疗后出现反复低烧。家人都十分着急，请问美国有什么新药么？

icefire · Post by **icefire** » 2005-09-11 0:53

知道的同学吱一声罢

lindamm · Post by **lindamm** » 2005-09-11 4:19

Roche/Genentech's Avastin is an oncology star, however I understand its indication for Lung cancer will only be non-small-cell.

Pfizer's Camptosar/Campto is working on small-cell-lung cancer PIII (will be in market 06/07), currently it is already for Colorectal cancer.

Both products are in the market, you may consult your doctor for more information.

I have not heard good products succesfully marketed in this area.

(sorry for my limited knowledge

)

Jun · Post by **Jun** » 2005-09-11 10:34

www.nci.nih.gov
http://www.cancer.gov/cancertopics/pdq/ ... ng/patient

I'm sorry to say there is very limited options for treatment. Surgery and radiation may prolong survival time in SC lung cancer without metastasis, but ... If your mom is in the U.S., perhaps you can try to enroll her in a clinical trial.

2 drugs mentioned on the Web site are not very promising for SCLC.
Bevacizumab (Avastin)
Gefitinib (Iressa)

lindamm · Post by **lindamm** » 2005-09-11 12:27

Thanks for Jun's web guidance, indeed good for apprentice as me.

Iressa was not seen as good efficacy in the recent clinical trials result on non-small-lung-cancer, so it is PTK/ZK on colorectal cancer...

Jun · Post by **Jun** » 2005-09-11 12:51

Sorry I didn't read the initial posting carefully. Fever may have been caused by infection due to chemotherapy rather than due to the cancer itself. To risk sounding morbid, I also suggest you talk to Hospice (if the patient is in the U.S.) or to the oncologist about the best option for palliative/supportive care.

helenClaire · Post by **helenClaire** » 2005-09-11 13:55

加个American Lung Association的连接：http://www.lungusa.org/site/pp.asp?c=dvLUK9O0E&b=38494

帮助患者做治疗决定的问卷：
https://www.cancerprofiler.nexcura.com/ ... p?CB=19608

晒太阳的猫 · Post by **晒太阳的猫** » 2005-09-11 14:10

谢谢谢谢大家。患者不是我妈妈，是朋友的姨父。我昨天查的资料也是说trial是目前比较好的选择，打算周一去问问，唯一可惜的是他人在国内，似乎不合乎要求。

遇见这种事情才格外感到生命的珍贵和脆弱，再次强烈感谢大家。谢谢。

sanxiao · Post by **sanxiao** » 2005-09-11 21:07

晒猫你可以让他试试参加国内的trial，一般要他的主治医来推荐，或者是问问美国的大夫有什么好药，打听他们在中国是否注册是否做临床，然后去相关的医院了解。

猫咪头 · Post by **猫咪头** » 2005-09-12 4:31

抱一下太阳猫. 我母亲也是首次化疗后出现反复低烧, 不过比起化疗进行中呕吐的滴水不进, 她本人还很乐观的跟我打电话说情况不错... 母亲是两周前确诊的非小细胞肺癌, 4 期. 爸爸还念叨说那怕是小细胞的还好些. 同病房成功出院的就是小细胞肺癌4次化疗以后病灶萎缩为0.

小细胞肺癌的化疗方案好像已经比较成熟: VAC: Vincristine, Adriamycin (which is also called doxorubicin) and Cyclophosphamide. 最好能继续化疗, 小细胞的增殖比较快.

猫咪头 · Post by **猫咪头** » 2005-09-12 4:49

如果不能继续化疗, 只好用副作用不大(但效果也不明显)的一些新药.

请问大家是否知道 Tarceva 这药怎么样?

另外我也谢谢 JUN, lindaMM 和 helen 提供的信息. lindaMM是当年要去新奥尔良学习的mm么？已经毕业了吧。

lindamm · Post by **lindamm** » 2005-09-12 8:43

猫咪头, thanks for remembering me

yeah, it was me.

Tarceva - Erlotinib, it has a label for treatment of advanced or metastatic non-small cell lung cancer (NSCLC) after the failure of at least one prior chemotherapy regimen, another product from Roche/Genentech. Doctors seems to be positive with the prospect of the product.

I took a look at the clinical trials that it has run, the results are kind of mixed:

1) the trial that supports its label are good (use Tarceva on patients who has previously undergone one to two chemotherapy)
2) the trial of a combination of Tarceva with chemotherapy in advanced-stage NSCLC patients was disappointing
3) Tarceva also has shown efficacy in bronchoalveolar cell carcinoma (BAC), a subtype of NSCLC

My key take-away is to use that not as a combination, but more of a monotherapy after chemotherapy.

猫咪头 · Post by **猫咪头** » 2005-09-12 9:48

你没有在水里就好。天地不仁，以万物为刍狗啊。

嗯，看来这第三代新药就像第7个小馒头，能不能吃饱人很大程度上取决于前头吃了些啥，以及本来饿得严重不严重。

就怕不是小馒头，是观音土。

钱真多 · Post by **钱真多** » 2005-09-14 2:13

晒猫是替我问的，谢谢大家！
我姨父第一个化疗疗程结束后反复发烧，直到今天仍有38、39度，原定的第二个疗程因此无法继续。他人在国内，现在暂时用中药，希望能把发烧压下去。
我姨父自己是医学教授，病起得十分蹊跷，一直咳嗽，但没有消瘦，拍X光也一直正常。这样咳了半年，家人终于起了疑心，做CT，还是正常，直到做加强CT，才发现已经是3A期。
在此提醒大家，长辈如果身体不适，检查一定要仔细，常规检查看来是无效的。

sanxiao · Post by **sanxiao** » 2005-09-14 2:38

真多你不是在杭州吗，或者可以试试上海肿瘤医院，他们有一套中西医结合的办法据说还比较有效

Jun · Post by **Jun** » 2005-09-14 6:25

如果化疗用的是杀到骨髓细胞的药，很有可能是感染，只要查一查白细胞数量就知道了。刺激白细胞生长的药也有(估计在中国也可以买到)，不过很贵很贵。

猫咪头 · Post by **猫咪头** » 2005-09-14 13:15

钱真多, 这样的高烧+白细胞下降很可能有炎症。建议考虑抗生素。

DeBeers · Post by **DeBeers** » 2005-09-14 14:58

I went to a talk by Harold Varmus yesterday, he mentioned Gleevec, Irresa, and Tarceva for cancer treatment. But I'm too far away from this field, don't know if they are good or not:(